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The values are expressed as mean SEM of three determinations

D.KoikeK.MoreauC.SansomM

doi: 10.1016/j.jcte.2021.100284 35 SalariNKhodayariYHosseinian-FarAZareiHRasoulpoorSAkbariHet al

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However, when Cys 129 residue of PTPN22 is mutated, the disulfide bond cannot form and the enzyme is exposed by oxidation, resulting in inactivation (93)