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While these data support the notion that high glucose contributes to reduced BBB integrity, at least in part through endothelial injury, there are conflicting reports on the endothelial barrier or TJ protein expression in the context of hyperglycemia

Because the effect is centrally mediated (originating in the brain), it can complement other therapies for sexual performance without relying solely on vascular stimulation

In addition, the inclusion of demographic, socioeconomic, and psychological factors provides a detailed picture of patterns of use and potential demand within different population subgroups

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