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For patient 3, this six-month intervention did appear successful, easing cravings and cutting down on binge-eating episodes, according to Halperns team
Michele Green in NYC
Conclusion GLP-1 medications like semaglutide and tirzepatide are among the most powerful tools ever developed for weight loss and metabolic health
Lower systemic bioavailability from nasal delivery would be expected to reduce the incidence and severity of these GI effects
The jump from 8mg to 12mg carries a disproportionate increase in GI symptoms relative to the modest additional weight loss
He's thinking about the future
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