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Once patients found out how effective these medications were, word of mouth really drove up demand and outpaced the ability of these drug companies to manufacture them, says Nate Wood, MD, a primary care doctor and co-leader of the weight management clinic at the New Haven Primary Care Consortium, part of Yale New Haven Hospital in Connecticut

Careful monitoring, including laboratory testing for certain anticoagulants, helps maintain safe treatment levels

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Visceral fat is metabolically more responsive to GLP-1 signaling than subcutaneous fat

Some patients worry that magnesium might reduce semaglutide's effectiveness