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Taking retatrutide immediately before or after a meal can minimize nausea

Important safety considerations include risk of thyroid C-cell tumors (contraindicated in MEN2 or personal/family history of medullary thyroid carcinoma), pancreatitis, gallbladder disease, hypoglycemia when used with insulin or secretagogues, and potential worsening of diabetic retinopathy in some patients

100% of participants at the highest dose lost at least 5% body weight

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However, the level of supervision varies, so patients should always ask about provider qualifications and follow-up care

Nausea can occur because the medication affects the digestive system, slowing gastric emptying and altering hunger signals