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The demonstration of cardiorenal benefits with SGLT2i in clinical trials both for participants with CKD and type 2 diabetes and for those without [23,24,25] and the updated 2022 KDIGO guidelines recommending SGLT2i as first-line therapy for patients with CKD and type 2 diabetes regardless of glycemic control [6] have likely driven a shift toward their broader use for preventive cardiorenal protection and earlier implementation for patients with type 2 diabetes

doi: 10.1007/s00125-016-3874-y, 37 FeinglosM

Can Ketones Help Rescue Brain Fuel Supply in Later Life

Constipation is common and does not automatically mean ileus or intestinal paralysis

Both semaglutide GLP-1 and liraglutide are part of a class of drugs used to help people manage their weight alongside diet and exercise

Interestingly, hyperplasia of selected EEC subtypes in response to intestinal infection is probably dependent on immune cells, since serotonin (5-HT)-producing cell hyperplasia associated with Citrobacter rodentium infection was absent in mice lacking adaptive immunity (53) and CD4 + T cells were necessary to increase numbers of 5-HT producing enterochromaffin cells during helminth infection (149)