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Additionally, metformin increases the bodys response to insulin, leading to increased movement of glucose from the bloodstream into cells

Eisenberg D, Azagury DE, Ghiassi S, et al

To put that in perspective, a 10 mg/kg dose in a 250-g rat, scaled allometrically to a 70-kg human using the FDA's body surface area conversion factor of 6.2, translates to roughly 1.6 mg/kg, or 112 mg for a 70-kg person 7

However, these trends have also driven the development of new drugs to treat the disease

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