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Although its uncertain what caused these conflicting results, all these clinical trials suffered from flaws such as small sample sizes and short duration

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Low concentrations of testosterone had no effects on cell viability , whereas at high concentrations the cell viability decreased with incremental increases in hormone concentration. The testosterone-induced apoptosis described in this study occurs through overactivation of intracellular Ca2+ signaling pathways

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Hence, it is possible that C2 and C3 play distinct roles in various molecular pathways associated with depression