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ASM is a distinct model separate from other payment programs

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Each layer involves separate litigation risk, separate PTAB inter partes review proceedings, and separate regulatory exclusivity analysis

Whilst all agents in this class can cause nausea, individual responses vary: Dulaglutide (Trulicity) is administered once weekly and some patients report fewer gastrointestinal effects Liraglutide (Victoza) requires daily injection but allows more gradual dose titration Exenatide (Byetta, Bydureon) is available in both short-acting (twice daily) and extended-release (once weekly) formulations Switching between GLP-1 agonists should be undertaken under medical supervision with appropriate dose adjustment and monitoring

Statements Author contributions MM-T wrote the first draft of the manuscript

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