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In a recent study [65], NF-B DNA-binding activity was dose-dependently attenuated in nephrotoxic rats administered a beetroot extract for 28 days (250 mg or 500 mgkgbm 1 )

Due to the rapid proliferation and metabolism of tumor cells, glycolysis is highly active, and the tumor microenvironment (TME) often exhibits characteristics of hypoxia and glucose deprivation